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D-alpha-Hydroxyglutaric acid disodium salt
D-alpha-Hydroxyglutaric acid disodium salt
CAS No. 103404-90-6
D-alpha-Hydroxyglutaric acid disodium salt ( D-2-HG;D-2-hydroxyglutarate )
Catalog No. M10168 CAS No. 103404-90-6
A competitive inhibitor of multiple α-KG-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
10MG | 42 | In Stock |
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25MG | 60 | In Stock |
|
50MG | 101 | In Stock |
|
100MG | 177 | In Stock |
|
200MG | 264 | In Stock |
|
500MG | Get Quote | In Stock |
|
1G | Get Quote | In Stock |
|
Biological Information
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Product NameD-alpha-Hydroxyglutaric acid disodium salt
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NoteResearch use only, not for human use.
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Brief DescriptionA competitive inhibitor of multiple α-KG-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases.
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DescriptionA competitive inhibitor of multiple α-KG-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases; partially and completely inhibits CeKDM7A demethylase at 50 mM and 100 mM, respectively; comptes with α-KG and inhibits KDM5B/JARID1B/PLU-1 with Ki of 10.87 mM; binds and inhibits ATP synthase and inhibit mTOR signaling in IDH1 mutant cells
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SynonymsD-2-HG;D-2-hydroxyglutarate
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PathwayChromatin/Epigenetic
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TargetHistone Demethylase
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Recptorα-KG
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number103404-90-6
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Formula Weight192.08
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Molecular FormulaC5H6Na2O5
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Purity>98% (HPLC)
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SolubilityH2O: ≥ 32 mg/mL
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SMILES[O-]C(CC[C@H](C([O-])=O)O)=O.[Na+].[Na+]
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Chemical NamePentanedioic acid, 2-hydroxy-, disodium salt, (2R)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Xu W, et al. Cancer Cell. 2011 Jan 18;19(1):17-30.
2. Fu X, et al. Cell Metab. 2015 Sep 1;22(3):508-15.
2. Fu X, et al. Cell Metab. 2015 Sep 1;22(3):508-15.
molnova catalog
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