Cart
sales@molnova.com
Home -
Products -
Chromatin/Epigenetic -
Histone Demethylase -
D-alpha-Hydroxyglutaric acid disodium salt
D-alpha-Hydroxyglutaric acid disodium salt
CAS No. 103404-90-6
D-alpha-Hydroxyglutaric acid disodium salt( D-2-HG | D-2-hydroxyglutarate )
Catalog No. M10168 CAS No. 103404-90-6
A competitive inhibitor of multiple α-KG-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 10MG | 42 | In Stock |
|
| 25MG | 60 | In Stock |
|
| 50MG | 101 | In Stock |
|
| 100MG | 177 | In Stock |
|
| 200MG | 264 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameD-alpha-Hydroxyglutaric acid disodium salt
-
NoteResearch use only, not for human use.
-
Brief DescriptionA competitive inhibitor of multiple α-KG-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases.
-
DescriptionA competitive inhibitor of multiple α-KG-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases; partially and completely inhibits CeKDM7A demethylase at 50 mM and 100 mM, respectively; comptes with α-KG and inhibits KDM5B/JARID1B/PLU-1 with Ki of 10.87 mM; binds and inhibits ATP synthase and inhibit mTOR signaling in IDH1 mutant cells.
-
In Vitro——
-
In Vivo——
-
SynonymsD-2-HG | D-2-hydroxyglutarate
-
PathwayChromatin/Epigenetic
-
TargetHistone Demethylase
-
Recptorα-KG
-
Research AreaCancer
-
Indication——
Chemical Information
-
CAS Number103404-90-6
-
Formula Weight192.08
-
Molecular FormulaC5H6Na2O5
-
Purity>98% (HPLC)
-
SolubilityH2O: ≥ 32 mg/mL
-
SMILES[O-]C(CC[C@H](C([O-])=O)O)=O.[Na+].[Na+]
-
Chemical NamePentanedioic acid, 2-hydroxy-, disodium salt, (2R)-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Xu W, et al. Cancer Cell. 2011 Jan 18;19(1):17-30.
2. Fu X, et al. Cell Metab. 2015 Sep 1;22(3):508-15.
molnova catalog
related products
-
SAH-EZH2
EZH2/EPP interaction inhibitor (Kd = 320 nM). Suppresses EZH2 expression and H3K27 trimethylation by PCR2 complex. Arrests proliferation and induces monocyte to macrophage differentiation of MLL-AF9 leukemia cell line.
-
SGC-iMLLT
SGC-iMLLT is a potent and selective MLLT1/3-histone interactions inhibitor(IC50 = 0.26 μM),and is a first-in-class chemical probe displaying cellular target engagement of MLLT1(Kd = 0.129?μM) and MLLT3(Kd = 0.077?μM).
-
ORY-1001
ORY-1001 (RG-6016, Ladademstat) is a highly potent, selective inhibitor of lysine-specific demethylase KDM1A (LSD1) with IC50 of 18 nM.
